Warning: if you like your glass half filled, if you are a positive thinker, if you are optimistic, if you think hope is good, then please don't read this article: it will attack your world at its core.
A society or a species that can have coherence and maintain that coherence is a species that survives most any calamity.
If you want to destroy a species (or and individual) you need to introduce incoherence.
Incoherence means: stuff is there that doesn't fit. That doesn't work well with the rest of the organism. That conflicts with the goals of the organism.